Association Between Papillary Thyroid Cancer and Primary Aldosteronism in Individuals With Hypertension - Summary - MDSpire

Association Between Papillary Thyroid Cancer and Primary Aldosteronism in Individuals With Hypertension

  • By

  • Ana Alice W Maciel

  • Debora L S Danilovic

  • Ibere C Soares

  • Thais C Freitas

  • Jessica Okubo

  • Gustavo F C Fagundes

  • Felipe Freitas-Castro

  • Lucas S Santana

  • Augusto G Guimaraes

  • Vinicius F Calsavara

  • Felipe L Ledesma

  • Luciana A Castroneves

  • Fernando M A Coelho

  • Victor Srougi

  • Fabio Y Tanno

  • Jose L Chambo

  • Francisco C Carnevale

  • João V Silveira

  • Fernanda M Consolim-Colombo

  • Luiz A Bortolotto

  • Luciana P Brito

  • Maria Candida B V Fragoso

  • Luciano F Drager

  • Celso E Gomez-Sanchez

  • Ana Claudia Latronico

  • Berenice B Mendonca

  • Ana O Hoff

  • Madson Q Almeida

  • September 18, 2024

  • 0 min

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Objective:

To investigate the association between primary aldosteronism (PA) and papillary thyroid cancer (PTC) in individuals with arterial hypertension (HT), highlighting the clinical significance of this relationship.

Key Findings:
  • Prevalence of PA was 29.20% (95% CI, 21.91%-37.68%) in the PTC group and 20.44% (95% CI, 14.22%-28.35%) in the controls (P = .093).
  • Frequency of severe HT was significantly lower in the PTC group (23%) compared to controls (73%; P < .001).
  • After matching by HT stage, PA prevalence was significantly higher in the PTC group (9.56%; 95% CI, 5.39%-16.1%; P < .0001).
  • PTC was independently associated with PA in both unmatched (OR 4.74; 95% CI, 2.26-10.55) and matched (OR 5.88; 95% CI, 2.79-13.37) HT individuals.
Interpretation:

The study suggests a significant association between PTC and PA in hypertensive individuals, indicating that PTC may be a risk factor for PA, with implications for clinical screening practices.

Limitations:
  • The study was limited to a single center and may not be generalizable, potentially affecting the external validity of the findings.
  • Potential biases in matching controls and the retrospective nature of data collection may influence the results.
Conclusion:

The findings support the recommendation for PA screening in patients with PTC, regardless of the severity of hypertension, emphasizing the need for clinical awareness.

Original Source(s)

Association Between Papillary Thyroid Cancer and Primary Aldosteronism in Individuals With Hypertension

  • by Ana Alice W Maciel, Debora L S Danilovic, Ibere C Soares, Thais C Freitas, Jessica Okubo, Gustavo F C Fagundes, Felipe Freitas-Castro, Lucas S Santana, Augusto G Guimaraes, Vinicius F Calsavara, Felipe L Ledesma, Luciana A Castroneves, Fernando M A Coelho, Victor Srougi, Fabio Y Tanno, Jose L Chambo, Francisco C Carnevale, João V Silveira, Fernanda M Consolim-Colombo, Luiz A Bortolotto, Luciana P Brito, Maria Candida B V Fragoso, Luciano F Drager, Celso E Gomez-Sanchez, Ana Claudia Latronico, Berenice B Mendonca, Ana O Hoff, Madson Q Almeida

  • September 18, 2024

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