Novel BPI3Vc-vectored chimeric BVDV antigens elicit broadly neutralizing antibodies in cattle - Summary - MDSpire

Novel BPI3Vc-vectored chimeric BVDV antigens elicit broadly neutralizing antibodies in cattle

  • By

  • Huldah Sang

  • Tae Kim

  • Rakshith Kumar

  • Jayden McCall

  • Aloysius Abraham

  • Tsvetoslav Koynarski

  • Michelle Zajac

  • Karim W. Abdelsalam

  • Daniela Hernandez Muguiro

  • Katherine Bauer

  • Brandon L. Plattner

  • Waithaka Mwangi

  • May 18, 2026

  • 0 min

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Objective:

To develop a live vaccine capable of inducing broad protection against diverse BVDV strains, particularly BVDV-1 and BVDV-2.

Key Findings:
  • The rBPI3VcmutBVDV vaccine elicited strong serum antibodies against BVDV-1 and -2 viruses, outperforming a commercial vaccine (p-values provided).
  • Significantly higher virus-neutralizing titers were observed against multiple BVDV strains, with specific statistical comparisons included.
  • Vaccinated calves showed improved health outcomes upon challenge with BVDV-1b CA0401186a, including steady weight gain and lower viremia.
Interpretation:

The study supports the potential of the BPI3Vc vector for developing broadly protective BVDV vaccines, which can be adapted for improved disease management.

Limitations:
  • The study primarily focused on a limited number of BVDV strains, which may not represent the full diversity of circulating strains.
  • Long-term efficacy and safety of the vaccine in field conditions remain to be evaluated.
Conclusion:

The BPI3Vc-vectored vaccine shows promise for enhancing BVDV control in cattle, addressing the limitations of current vaccines and suggesting a need for further research.

Original Source(s)

Novel BPI3Vc-vectored chimeric BVDV antigens elicit broadly neutralizing antibodies in cattle

  • by Huldah Sang, Tae Kim, Rakshith Kumar, Jayden McCall, Aloysius Abraham, Tsvetoslav Koynarski, Michelle Zajac, Karim W. Abdelsalam, Daniela Hernandez Muguiro, Katherine Bauer, Brandon L. Plattner, Waithaka Mwangi

  • May 18, 2026

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