Retrospective Analysis of Direct-Acting Antiviral Treatment Outcomes in Hepatitis C Patients in Saudi Arabia Before and After Therapy - Summary - MDSpire

Retrospective Analysis of Direct-Acting Antiviral Treatment Outcomes in Hepatitis C Patients in Saudi Arabia Before and After Therapy

  • By

  • Fatimah Salem Alayidh

  • Alexander Woodman

  • Nawaf Yahya Zakary

  • Rehab Yusuf Al-Ansari

  • Sharjeel Chaudhry

  • Amal Omar Alsaadi

  • Khadijah Ahmad Alharbi

  • Batool Abdullah Alamri

  • Shahad Mousa Alhomud

  • Shahad Hassan Albather

  • Sarah Abdullah Bataweel

  • Nouf Ahmed Madkhali

  • Samira Jamaan Alzahrani

  • Zarmina Ehtesham

  • February 2, 2026

  • 0 min

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Objective:

To assess real-world treatment outcomes, including sustained virologic response rates and genotype distribution, of direct-acting antivirals (DAAs) among HCV-infected patients following Saudi Arabia’s national elimination campaign.

Key Findings:
  • 144 patients met the inclusion criteria for analysis.
  • DAA therapy resulted in a sustained virologic response (SVR) rate exceeding 90%, indicating effective treatment.
  • A high proportion of patients had indeterminate genotypes, highlighting diagnostic challenges and the need for improved genotyping methods.
Interpretation:

The study demonstrates the effectiveness of DAAs in achieving high SVR rates among HCV patients in Saudi Arabia, contributing valuable data on treatment outcomes and genotype distribution.

Limitations:
  • The study was limited to a single region in Saudi Arabia, which may affect generalizability to other regions.
  • Exclusion of patients under 18 years limits understanding of DAA efficacy in younger populations, which may differ from adults.
Conclusion:

The introduction of DAAs has significantly improved treatment outcomes for HCV patients in Saudi Arabia, with high SVR rates observed in a real-world setting, underscoring the success of the national elimination campaign.

Original Source(s)

Retrospective Analysis of Direct-Acting Antiviral Treatment Outcomes in Hepatitis C Patients in Saudi Arabia Before and After Therapy

  • by Fatimah Salem Alayidh, Alexander Woodman, Nawaf Yahya Zakary, Rehab Yusuf Al-Ansari, Sharjeel Chaudhry, Amal Omar Alsaadi, Khadijah Ahmad Alharbi, Batool Abdullah Alamri, Shahad Mousa Alhomud, Shahad Hassan Albather, Sarah Abdullah Bataweel, Nouf Ahmed Madkhali, Samira Jamaan Alzahrani, Zarmina Ehtesham

  • February 2, 2026

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