To report a rare case of an IDH1-mutant astrocytoma diagnosed during pregnancy and to contribute to the literature on high-grade glioma management in such scenarios, emphasizing the need for improved clinical guidelines.
Key Findings:
The patient had a heterozygous CDKN2A/B deletion, indicating a poor prognosis despite the favorable IDH mutation status, highlighting the need for careful monitoring.
The tumor recurred rapidly within five weeks after initial surgery, necessitating further intervention, underscoring the aggressive nature of this subtype.
Both mother and infant survived the perioperative period without complications, but the patient passed away within two years of diagnosis, illustrating the challenges in managing such cases.
Interpretation:
The presence of CDKN2A/B deletion may define a more aggressive subtype of IDH-mutant astrocytoma, emphasizing the urgent need for clinical guidelines for managing high-grade gliomas in pregnancy.
Limitations:
The case highlights the lack of standardized treatment guidelines for high-grade gliomas diagnosed during pregnancy, with few studies addressing this issue.
Limited literature exists on the management of such cases, making it difficult to draw broader conclusions and necessitating further research.
Conclusion:
Timely neurosurgical intervention and multidisciplinary care are crucial for managing high-grade gliomas in pregnant patients, and this case underscores the need for improved clinical guidelines.
by Muratbek A. Tleubergenov, Altynay Bakbayeva, Daniyar K. Zhamoldin, Aidos Doskaliyev, Ulday M. Urazova, Aigul D. Tolepbergenova, Aisa Z. Nurpeisov, Zhanat T. Takenov, Serik Akshulakov
