COVID-19 Vaccination in Pregnancy: Efficacy of Second-Generation Vaccines, Maternal-Neonatal Safety, and Strategies to Address Vaccine Hesitancy - Summary - MDSpire

COVID-19 Vaccination in Pregnancy: Efficacy of Second-Generation Vaccines, Maternal-Neonatal Safety, and Strategies to Address Vaccine Hesitancy

  • By

  • Xu, Jia

  • Liu, Fang

  • Yuan, Han-Ying

  • Pan, Heng

  • Xi, Xuan

  • Chen, Che

  • Li, De-Hong

  • LU, Yan

  • May 22, 2026

  • 0 min

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Objective:

To evaluate current vaccination strategies for pregnant women using second-generation COVID-19 vaccines, focusing on their effectiveness and safety, and analyze barriers to vaccine uptake.

Key Findings:
  • Pregnant women are at increased risk for severe COVID-19 outcomes, including ICU admission and maternal mortality, particularly with the Omicron variant.
  • Physiological changes during pregnancy can worsen respiratory function in infected individuals.
  • Robust evidence supports the efficacy and safety of COVID-19 vaccines, yet vaccine hesitancy persists.
Interpretation:

The review underscores the need for further research to refine vaccination protocols, address vaccine hesitancy, and support equitable access to vaccines for pregnant women.

Limitations:
  • The review highlights ongoing concerns about potential adverse effects and fetal safety that contribute to vaccine hesitancy, and may not cover all demographic factors influencing this hesitancy.
Conclusion:

Further research is necessary to ensure the safe and effective deployment of COVID-19 vaccines during pregnancy.

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