To investigate the association between preoperative proteinuria and renal functional outcomes after partial nephrectomy (PN) for renal cell carcinoma (RCC), highlighting its potential clinical significance.
Key Findings:
22 out of 295 patients (7.4%) had preoperative proteinuria.
Patients with preoperative proteinuria had a higher proportion of CKD stage III or higher (31.8% vs 5.1%).
No significant difference in renal function decline between patients with and without preoperative proteinuria.
Lower baseline eGFR was the only independent predictor of CKD stage III or higher, indicating the need for careful monitoring.
Interpretation:
Preoperative proteinuria is associated with a higher prevalence of CKD but does not significantly predict renal function decline post-surgery, suggesting the need for further investigation into other predictive factors.
Limitations:
Single-center study may limit generalizability; future multi-center studies could enhance applicability.
Retrospective design may introduce selection bias; prospective studies are recommended to validate findings.
Conclusion:
While preoperative proteinuria correlates with CKD prevalence, it does not independently predict long-term renal function decline after PN for RCC, underscoring the importance of comprehensive preoperative assessments.
The Lank Center for Genitourinary Oncology at Dana-Farber Cancer Institute presents a succinct summary of all the kidney cancer clinical updates, focused on clear cell renal cell carcinoma (ccRCC), you need to know from GU ASCO 2025.
