Lipoprotein(a) and Risk of Treated Ventricular Arrhythmias in Heart Failure - Summary - MDSpire

Lipoprotein(a) and Risk of Treated Ventricular Arrhythmias in Heart Failure

  • By

  • Ramzi Ibrahim

  • Luke Dreher

  • Hussein Abdul Nabi

  • Juan Maria Farina

  • Eiad Habib

  • Hoang Nhat Pham

  • Min Choon Tan

  • Hussein A. Noureldine

  • Sammudeen Ibrahim

  • Mayurkumar Bhakta

  • Kwan Lee

  • Dan Sorajja

  • Win-Kuang Shen

  • Luis R. Scott

  • Chadi Ayoub

  • Reza Arsanjani

  • Hicham Z. El Masry

  • May 26, 2026

  • 0 min

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Objective:

To evaluate the association between elevated lipoprotein(a) [Lp(a)] and treated ventricular arrhythmias among adults with heart failure with reduced ejection fraction (HFrEF) undergoing ICD implantation.

Key Findings:
  • Among 595 patients, 25.8% with elevated Lp(a) received appropriate ICD shocks compared to 9.6% with lower Lp(a).
  • Elevated Lp(a) was associated with an increased risk of appropriate shocks (adjusted HR 2.95; P < .001).
  • No significant difference in all-cause mortality between groups (adjusted HR 0.80; P = .15).
Interpretation:

Elevated Lp(a) was associated with increased risk of treated ventricular arrhythmias but did not correlate with higher mortality.

Limitations:
  • Retrospective design and potential residual confounding.
  • Intersite variation in ICD programming.
  • Selection bias due to non-comparison of included and non-included patients.
Conclusion:

Further prospective studies are warranted.

Original Source(s)

Lipoprotein(a) and Risk of Treated Ventricular Arrhythmias in Heart Failure

  • by Ramzi Ibrahim, Luke Dreher, Hussein Abdul Nabi, Juan Maria Farina, Eiad Habib, Hoang Nhat Pham, Min Choon Tan, Hussein A. Noureldine, Sammudeen Ibrahim, Mayurkumar Bhakta, Kwan Lee, Dan Sorajja, Win-Kuang Shen, Luis R. Scott, Chadi Ayoub, Reza Arsanjani, Hicham Z. El Masry

  • May 26, 2026

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