Retinal Changes Linked to PCOS - Summary - MDSpire
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Retinal Changes Linked to PCOS
Meta-analysis of OCT and OCT angiography studies found thicker retinal nerve fiber layers and slightly thinner central macula in patients with polycystic ovary syndrome.
To evaluate retinal and choroidal structural differences in patients with polycystic ovary syndrome (PCOS) compared to healthy controls using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).
Approach:
Key Findings:
PCOS patients had thicker average peripapillary RNFL by about 4 µm compared to controls.
Central macular thickness was reduced by about 3 µm in PCOS patients.
Choroidal thickness was thicker in PCOS patients by about 58 µm, but with substantial heterogeneity.
No consistent differences in retinal microvascular density between PCOS patients and controls.
Localized retinal differences were noted, with increased ganglion cell complex thickness in PCOS patients.
Interpretation:
Structural retinal and choroidal alterations may occur in PCOS patients despite unchanged retinal microvascular density, indicating potential remodeling.
Limitations:
Most studies were conducted in a single geographic region, limiting generalizability.
Variability in OCT devices and imaging protocols may affect measurement consistency.
Inconsistent reporting of body mass index and disease duration.
All studies were observational, preventing causal inference.
Conclusion:
The systematic review and meta-analysis indicates evidence of retinal and choroidal structural changes linked to PCOS.
