To assess the burden of cardiometabolic factors and their associations with cardiovascular disease (CVD) among young adult cancer survivors (aged 19-39 years at diagnosis), while exploring ethnic disparities.
Key Findings:
Cardiometabolic factors were more prevalent in cancer survivors compared to non-cancer participants.
Significant associations were found between Type 2 diabetes and increased odds of myocardial infarction (OR: 6.99; 95% CI: 3.45–14.19) and congestive heart failure (OR: 12.304; 95% CI: 7.23–20.91).
Hypertension was strongly associated with congestive heart failure (OR: 20.48; 95% CI: 11.79–35.57).
Racial/ethnic disparities in cardiometabolic factors and CVD risk were observed.
Interpretation:
Cardiometabolic factors independently contribute to elevated CVD risk in young adult cancer survivors, highlighting the urgent need for integrated risk assessment and prevention strategies in survivorship care.
Limitations:
Retrospective design may limit causality conclusions.
Potential confounding factors not accounted for in the analysis.
Data limited to a single healthcare system may affect generalizability and diversity of the sample.
Conclusion:
Young adult cancer survivors face significant cardiometabolic risks that increase their likelihood of developing cardiovascular diseases, highlighting the need for proactive management and early screening.
