To report two cases of malignant transformation of deep infiltrating endometriosis (DIE), a rare occurrence, and review existing literature.
Approach:
Key Findings:
Both cases involved patients with hydronephrosis and extensive DIE lesions.
Postoperative pathology confirmed well-differentiated endometrioid adenocarcinoma in both cases.
Endometrioid adenocarcinoma was the most frequently observed histological subtype in the literature review.
Interpretation:
Diagnosis of malignant transformation in DIE is challenging due to nonspecific clinical manifestations and the overlap with benign DIE, highlighting the need for increased clinical awareness.
Limitations:
No standardized management strategy exists for malignant transformation of DIE, with limited evidence regarding the incidence and management approaches.
Conclusion:
A multidisciplinary approach combining complete surgical resection with adjuvant therapy is supported by current evidence, emphasizing the need for early diagnosis and awareness of malignant potential in DIE.
