Biocompatibility and Contact Lens Wear - Summary - MDSpire
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Biocompatibility and Contact Lens Wear

In this feature, Alex Hui, OD, PhD, looks at the research and determines that contact lenses could be considered one of the most successful examples of biocompatible devices used. He further examines contact lens dropout and how to achieve contact lens wear success.

  • By

  • Alex Hui, OD, PhD, FAAO

  • June 1, 2025

  • 14 min

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Objective:

To explore the evolution of biocompatibility in contact lens materials and their impact on long-term wear success, emphasizing the relationship between material properties and user experience.

Approach:
    Key Findings:
    • Contact lenses have over 140 million wearers globally, indicating their effectiveness in addressing vision correction needs.
    • PMMA lenses improved wearability but revealed significant biocompatibility issues, particularly regarding oxygen transmission during long-term use.
    • Silicone hydrogels significantly reduce hypoxia-related complications but do not eliminate all issues associated with overnight wear, leading to ongoing discomfort for some users.
    Interpretation:

    The evolution of contact lens materials reflects ongoing efforts to enhance biocompatibility and user comfort, yet challenges remain, particularly dropout rates due to discomfort linked to material properties.

    Limitations:
    • Mixed evidence in literature regarding contact lens dropout complicates understanding and addressing the issue, with varying reports on user experiences.
    • Some complications persist despite advancements in material technology, particularly in relation to long-term wear and user comfort.
    Conclusion:

    While significant progress has been made in contact lens technology to improve biocompatibility and comfort, dropout rates due to ocular discomfort remain a challenge, necessitating further research and innovation.

Original Source(s)

Biocompatibility and Contact Lens Wear

  • by Alex Hui, OD, PhD, FAAO

  • June 1, 2025

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