Autoimmune thyroiditis and comorbid autoimmune diseases: global research landscape and future directions - Summary - MDSpire

Autoimmune thyroiditis and comorbid autoimmune diseases: global research landscape and future directions

  • By

  • Jie Tian

  • Feng Guo

  • Hao-Han Rao

  • Wan-Chen Xie

  • Xin-Yu Li

  • Huan-Wen Chen

  • July 16, 2026

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Objective:

To analyze the global research landscape of autoimmune thyroiditis (AIT) and its relationship with coexisting autoimmune diseases (ADs), identifying research trends and future directions.

Approach:
  • Data Extraction: Data was extracted from PubMed, Web of Science Core Collection, and Scopus, analyzing 2,201 publications from 1980 to 2024.
  • Data Visualization: Visualization was performed using VOSviewer, CiteSpace, and the bibliometrix R package.
Key Findings:
  • The analysis encompassed 95 countries, 2,561 institutions, and 10,355 authors, with publications across 769 sources.
  • The United States led in the number of published articles, while the University of Pisa emerged as the most productive institution.
  • The Journal of Clinical Endocrinology & Metabolism had the highest volume of publications and citations in this field.
  • Alessandro Antonelli was identified as the most prolific author, with the highest number of co-cited authors.
  • Keyword analysis identified five primary areas of research: immune dysregulation and inflammation mechanisms, comorbidity phenomena and shared pathological foundations, immune disturbances in infections and pregnancy, genetic susceptibility and genetic mechanisms, and biomarkers and cancer risk.
Interpretation:

The study provides insights into global research trends and highlights key areas for future investigation in the context of AIT and coexisting autoimmune disorders.

Limitations:
  • The study is limited to bibliometric analysis and may not capture all nuances of clinical and biological research.
  • Focus on publications may overlook ongoing research not yet published.
Conclusion:

The study offers a comprehensive overview of the literature on autoimmune disorders and autoimmune thyroiditis, suggesting future research directions.

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