To investigate associations between static anatomical geometry and planned dosimetric endpoints in prostate radiotherapy, focusing on OAR dose metrics.
Approach:
Data Analysis: Analyzed 37 patients from four centers using planning CT and DICOM-RT objects. Extracted geometric features of targets and organs at risk (OARs) and evaluated their associations with planned dosimetric endpoints.
Quality Control: Performed a systematic QC audit for atypical dose results and assessed workflow applicability in a real-world clinical setting using an independent institutional DICOM cohort.
Key Findings:
Bladder volume and longitudinal extent showed consistent associations with multiple bladder DVH endpoints.
Prescription-normalized sensitivity analyses indicated similar bladder-related patterns.
Near-zero bladder D2cc values were interpreted as reflecting geometric separation from the high-dose region.
The processing workflow was successfully applied to an independent institutional DICOM cohort.
Interpretation:
Inter-patient anatomical geometry was associated with planned OAR dosimetric endpoints within a static planned-dose DVH evaluation.
Limitations:
Residual inter-patient and interfraction anatomical changes remain frequent and cannot be fully eliminated.
Inconsistent ROI semantics can hinder harmonization and reduce cross-center comparability.
Conclusion:
The study clarifies associations between static anatomical geometry and planned dosimetric endpoints in prostate radiotherapy.
