Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy–Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials - Summary - MDSpire

Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy–Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • By

  • Bingyan Gong

  • Nisha Yao

  • Hangxin Xie

  • Chuncheng Huang

  • Tomoko Kishimoto

  • Howard Berenbaum

  • Wenting Mu

  • May 8, 2026

  • 0 min

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Objective:

To evaluate the therapeutic efficacy of CBT-oriented chatbots for adults with depressive and/or anxiety symptoms, explore potential moderators of intervention efficacy, and synthesize evidence on user engagement and acceptability, highlighting their importance in treatment outcomes.

Key Findings:
  • CBT-oriented chatbots show mixed results in reducing depressive and/or anxiety symptoms, with engagement and acceptability being critical factors influencing effectiveness.
Interpretation:

The efficacy of CBT-oriented chatbots remains inconsistent, highlighting the need for further research to clarify their therapeutic potential, identify specific moderators, and improve user engagement.

Limitations:
  • Existing reviews lack quantitative synthesis and sufficient statistical power.
  • Inconsistent outcome assessments and inclusion of nontarget populations may skew results.
  • Limited exploration of moderators affecting efficacy, and potential lack of diversity in study populations.
Conclusion:

This study establishes an evidence base for the effectiveness and user experience of CBT-oriented chatbots, addressing the urgent need for accessible digital mental health solutions and the barriers to access in mental health care.

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