To summarize the expression profile, functional mechanisms, and clinical significance of lncRNA PVT1 in Oral Squamous Cell Carcinoma (OSCC), highlighting its potential as a therapeutic target.
Key Findings:
lncRNA PVT1 is frequently overexpressed in OSCC and correlates with advanced TNM stage and poor survival.
PVT1 acts as a competitive endogenous RNA (ceRNA), sequestering tumor-suppressive microRNAs and promoting tumor cell proliferation.
PVT1 modulates key signaling pathways, including the Wnt/β-catenin pathway and is regulated by m6A methylation, driving OSCC progression.
Interpretation:
lncRNA PVT1 plays a crucial role in OSCC pathogenesis and may serve as a promising target for therapeutic intervention and a biomarker for diagnosis, warranting further research.
Limitations:
The review primarily focuses on lncRNA PVT1 without extensive exploration of other lncRNAs in OSCC, which may limit broader insights.
Further clinical studies are needed to validate the therapeutic potential of targeting lncRNA PVT1 and its mechanisms.
Conclusion:
lncRNA PVT1 is a significant contributor to OSCC progression and presents opportunities for improved diagnostic and therapeutic strategies, highlighting the need for further validation.
