Abnormal active myocardial relaxation by dipyridamole stress test in suspected early-stage heart failure with preserved ejection fraction: a retrospective exploratory analysis - Summary - MDSpire
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Abnormal active myocardial relaxation by dipyridamole stress test in suspected early-stage heart failure with preserved ejection fraction: a retrospective exploratory analysis
To evaluate left ventricular (LV) mechanics in patients with suspected early-stage heart failure with preserved ejection fraction (HFpEF) using dipyridamole stress echocardiography (DipSE).
Key Findings:
E/e′ ratio increased significantly in suspected early-stage HFpEF patients (p < 0.001), but not in HHD patients.
IVRT remained significantly higher in suspected early-stage HFpEF patients during stress (p < 0.001), while it reduced in HHD patients (p = 0.002).
MPI improved during DipSE in HHD patients (p = 0.005), but not in suspected early-stage HFpEF patients.
MPI was worse in suspected early-stage HFpEF patients with ST-segment depression compared to those without it (p = 0.05).
Interpretation:
In suspected early-stage HFpEF, increased LV filling pressure during DipSE is associated with abnormal active myocardial relaxation.
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability.
Small sample size may affect the robustness of the findings.
Conclusion:
Myocardial performance is particularly impaired in patients with suspected early-stage HFpEF who exhibit ST-segment depression during DipSE.
by Gabriella Locorotondo, Monica Filice, Francesca Augusta Gabrielli, Giacomo Moretti, Laura Manfredonia, Antonella Lombardo, Gaetano Antonio Lanza, Leonarda Galiuto
