To assess the prevalence of altered body composition parameters in patients with Klinefelter and Kallmann syndromes and to compare body composition between the two groups, including associations with bone mineral density (BMD) and serum follicle-stimulating hormone (FSH) levels.
Key Findings:
Radiologic sarcopenic obesity identified in 14% of patients (6 Klinefelter, 1 Kallmann).
Osteosarcopenic obesity found in 4% of patients, both with Klinefelter syndrome.
Kallmann syndrome patients had significantly higher ALMI values than Klinefelter syndrome patients (8.37 ± 1.15 vs 7.28 ± 1.20 kg/m²; P < .001).
Inverse association between FSH levels and ALMI was statistically significant (B = −0.030; P = .0022).
Interpretation:
The study indicates a significant difference in lean mass between Klinefelter and Kallmann syndromes, suggesting a potential role for FSH in modulating muscle mass independent of testosterone levels, highlighting the need for further investigation.
Limitations:
Single-center study may limit generalizability.
Retrospective design may introduce selection bias.
Exclusion of patients with confounding factors may affect the findings, potentially skewing results.
Conclusion:
This study highlights the differences in body composition between Klinefelter and Kallmann syndromes and suggests that FSH may influence muscle mass.
