A systematic review of semaglutide-associated kidney injury case reports - Summary - MDSpire

A systematic review of semaglutide-associated kidney injury case reports

  • By

  • Xian Xiu

  • Pan-pan Zheng

  • Yang Li

  • Meng Du

  • Xi Min

  • Xiaohua Pang

  • Lili Zhang

  • Jingtao Liu

  • Zhe Zhao

  • Zan-chao Liu

  • Cai-Xia Feng

  • June 1, 2026

  • 0 min

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Objective:

To summarize reported cases and case series of semaglutide-associated renal injury and their clinical and laboratory features.

Key Findings:
  • 20 cases (7 males and 13 females) were included from 18 studies, with ages ranging from 29 to 83 years.
  • ADRs included acute kidney injury (AKI), acute renal failure (ARF), and acute interstitial nephritis (AIN), occurring at standard doses of semaglutide.
  • 12 cases were diagnosed through renal biopsy; 8 based on renal function parameters.
  • 17 patients improved or recovered following treatment, while outcomes were not reported for two patients, and one did not recover.
Interpretation:

Limitations:
  • The study is limited to case reports and series, which may not represent the broader population.
  • The small number of cases limits the ability to generalize findings.
Conclusion:

Original Source(s)

A systematic review of semaglutide-associated kidney injury case reports

  • by Xian Xiu, Pan-pan Zheng, Yang Li, Meng Du, Xi Min, Xiaohua Pang, Lili Zhang, Jingtao Liu, Zhe Zhao, Zan-chao Liu, Cai-Xia Feng

  • June 1, 2026

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