The effect of probiotic supplements on cognitive outcomes and neuroplasticity in elderly ischemic stroke survivors - Summary - MDSpire

The effect of probiotic supplements on cognitive outcomes and neuroplasticity in elderly ischemic stroke survivors

  • By

  • Xiaohong Zheng

  • Wei Chen

  • Kai Hong

  • Jiaqing Chen

  • Yuebin Lin

  • Jiehua Yang

  • June 22, 2026

  • 0 min

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Objective:

To investigate the effects of probiotic supplementation on the nutritional, cognitive, and motor functions of elderly survivors recovering from ischemic stroke.

Approach:
    Key Findings:
    • Post-treatment, the Supplement Group showed significant improvements in neurotrophic and nutritional parameters including BDNF, hemoglobin, albumin, and prealbumin levels (p ≤ 0.011).
    • Cognitive function improved in the Supplement Group with higher MMSE and HDS scores and reduced CDR scores (p < 0.003).
    • Motor function showed enhanced mobility and basic activities in the Supplement Group (p ≤ 0.014).
    • Functional recovery was better in the Supplement Group with decreased mRS scores and increased MBI scores (p < 0.004).
    • The incidence of gastrointestinal adverse events was significantly reduced in the Supplement Group (p < 0.001).
    Interpretation:

    Limitations:
    • The study is retrospective and may be subject to selection bias.
    • The sample size, while substantial, may not be representative of all elderly ischemic stroke survivors.
    Conclusion:

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