Accuracy of frameless stereotactic brain biopsy: a retrospective cohort study with MRI-only and MRI-CT fusion navigation - Summary - MDSpire

Accuracy of frameless stereotactic brain biopsy: a retrospective cohort study with MRI-only and MRI-CT fusion navigation

  • By

  • Franziska Meinert

  • Patrick Dömer

  • Simeon O. A. Helgers

  • Levent Tanrikulu

  • Johannes Woitzik

  • Nikhil Wendt-Thakur

  • December 20, 2025

  • 0 min

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Objective:

To analyze the accuracy and safety of frameless stereotactic biopsies using MRI-only and MRI-CT fusion navigation, emphasizing the importance of histopathological confirmation for treatment planning.

Key Findings:
  • Frameless stereotactic biopsies demonstrated comparable accuracy and complication rates between MRI-only and MRI-CT fusion navigation, highlighting the need for careful technique selection based on clinical scenarios.
  • Lesion volume and biopsy trajectory significantly influenced diagnostic yield.
  • MRI guidance may be affected by geometric distortions, which can be mitigated by CT fusion.
Interpretation:

The study suggests that both MRI-only and MRI-CT fusion navigation are effective for frameless stereotactic biopsies, with the choice depending on specific clinical scenarios and the potential impact on patient outcomes.

Limitations:
  • Non-randomized group allocation may introduce bias, potentially affecting the reliability of the findings.
  • Limited data on direct comparisons between MRI-only and MRI-CT fusion navigation in larger cohorts.
Conclusion:

Frameless stereotactic biopsy using either navigation technique is safe and accurate, with MRI-CT fusion potentially offering advantages in specific cases, underscoring the need for tailored approaches in clinical practice.

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