Objective:

To compare gut microbiota and metabolic profiles between post-cholecystectomy patients with and without metabolic syndrome.

Approach:

Key Findings:

• Patients with metabolic syndrome exhibited reduced microbial richness, reflected by lower Chao1 richness, while Shannon and Simpson indices were not significantly different.
• The metabolic syndrome group showed a lower Firmicutes/Bacteroidetes ratio, increased abundance of Prevotella, and decreased abundance of Bacteroides, Faecalibacterium, and Roseburia.
• Metabolomic analysis revealed elevated secondary bile acids and diminished short-chain fatty acids, particularly butyrate, in the metabolic syndrome group.
• Correlation analysis linked microbiota and metabolomic changes to inflammatory markers and adverse metabolic indices.

Interpretation:

Distinct gut microbial and metabolomic profiles were identified in post-cholecystectomy patients with metabolic syndrome, associated with inflammatory and metabolic indicators.

Limitations:

• The study is retrospective and cross-sectional, limiting causal inference.
• Existing studies on this topic are often limited by small cohorts.

Conclusion:

Among patients with a history of cholecystectomy, those with metabolic syndrome exhibited distinct gut microbial and metabolomic profiles compared with non-metabolic syndrome patients.

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