Serial prenatal MRI evaluation of valacyclovir-treated vs untreated fetuses with congenital cytomegalovirus (cCMV) infection - Summary - MDSpire

Serial prenatal MRI evaluation of valacyclovir-treated vs untreated fetuses with congenital cytomegalovirus (cCMV) infection

  • By

  • Mario Tortora

  • Elisa Fabbri

  • Alessia Arossa

  • Milena Furione

  • Luisa Chiapparini

  • Guglielmo Conti

  • Giana Izzo

  • Cecilia Parazzini

  • Filippo Arrigoni

  • Stefania Criscuolo

  • Fabio Tortora

  • Mariano Lanna

  • Andrea Righini

  • Chiara Doneda

  • June 20, 2026

  • 0 min

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Objective:

To compare serial prenatal MRI findings between valacyclovir-treated and untreated fetuses with confirmed congenital cytomegalovirus (cCMV) infection, focusing on isolated 'minor' lesions.

Approach:
    Key Findings:
    • Fetal MRI can detect subtle brain abnormalities associated with cCMV infection.
    • The study focused on the occurrence and progression of isolated 'minor' lesions.
    • Valacyclovir treatment was hypothesized to influence the development of these subtle MRI abnormalities.
    Interpretation:

    The study aims to assess the potential impact of valacyclovir on the evolution of minor brain lesions in fetuses with cCMV infection.

    Limitations:
    • Neonatal MRI findings and postnatal outcomes were not available for all cases.
    • The study was limited to a single center and a small sample size for the treated group.
    Conclusion:

    The study provides insights into the effects of valacyclovir on MRI findings in fetuses with cCMV, specifically regarding the occurrence and progression of minor lesions.

Original Source(s)

Serial prenatal MRI evaluation of valacyclovir-treated vs untreated fetuses with congenital cytomegalovirus (cCMV) infection

  • by Mario Tortora, Elisa Fabbri, Alessia Arossa, Milena Furione, Luisa Chiapparini, Guglielmo Conti, Giana Izzo, Cecilia Parazzini, Filippo Arrigoni, Stefania Criscuolo, Fabio Tortora, Mariano Lanna, Andrea Righini, Chiara Doneda

  • June 20, 2026

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