Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial - Summary - MDSpire

Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial

  • By

  • Yonghao Li

  • Yutong Wang

  • Ruikang Liu

  • Xuanchun Huang

  • Shiyi Tao

  • FuYuan Zhang

  • Jun Li

  • JingRun Cui

  • June 11, 2026

  • 0 min

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Objective:

To evaluate the efficacy and safety of Guipi Mixture combined with metoprolol for treating premature ventricular contractions (PVCs) associated with heart-spleen deficiency syndrome.

Approach:
    Key Findings:
    • PVCs are common arrhythmias that can lead to serious cardiovascular issues.
    • Current treatments include pharmacotherapy and catheter ablation, with metoprolol being a first-line drug.
    • Guipi Mixture is a traditional Chinese medicine that may enhance treatment efficacy.
    Interpretation:

    Limitations:
    • The study is limited to specific centers in China, which may affect generalizability.
    • Potential biases in patient selection and reporting of outcomes.
    Conclusion:

    The trial will assess the combined effects of Guipi Mixture and metoprolol on PVCs.

    Sources:

Original Source(s)

Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial

  • by Yonghao Li, Yutong Wang, Ruikang Liu, Xuanchun Huang, Shiyi Tao, FuYuan Zhang, Jun Li, JingRun Cui

  • June 11, 2026

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