The role of gut dysbiosis in endocrine and metabolic derangements of chronic kidney disease: mechanisms, controversies, and future perspectives - Summary - MDSpire
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The role of gut dysbiosis in endocrine and metabolic derangements of chronic kidney disease: mechanisms, controversies, and future perspectives
To summarize current evidence linking alterations in gut microbial composition and function to endocrine and metabolic derangements in chronic kidney disease (CKD).
Key Findings:
Gut dysbiosis promotes the accumulation of uremic toxins while reducing beneficial metabolites.
Altered gut microbiota contributes to complications such as CKD-MBD, vascular calcification, insulin resistance, and cognitive dysfunction.
The term 'dysbiosis' lacks a universally accepted definition, complicating its application in CKD.
Interpretation:
Gut dysbiosis is a mechanistically relevant factor in CKD that may be modifiable, influencing endocrine and metabolic complications.
Limitations:
Incomplete mechanistic validation of gut microbiota effects.
Limited longitudinal and interventional data.
Inadequate integration of multi-omics approaches.
Conclusion:
Understanding microbiota–metabolite–host interactions may support precision nutrition and microbiota-targeted therapies in CKD.
