The effect of pectin-supplemented enteral nutrition in mechanically ventilated patients receiving gastric feeding: protocol of a multicenter, open-label, randomized controlled trial (the PROMOTE trial) - Summary - MDSpire

The effect of pectin-supplemented enteral nutrition in mechanically ventilated patients receiving gastric feeding: protocol of a multicenter, open-label, randomized controlled trial (the PROMOTE trial)

  • By

  • Zirui Liu

  • Yizhen Xu

  • Yuan Ding

  • Lin Gao

  • Ruixin Bai

  • Cheng Lv

  • Qian Li

  • Man Li

  • Yingqiao Bai

  • Xiang Li

  • Wei Qin

  • Wangye Wu

  • Wencheng Yang

  • Zhengquan Wang

  • Jun Lu

  • Yuxiu Liu

  • Lu Ke

  • Feng Zheng

  • Baiqiang Li

  • Weiqin Li

  • June 23, 2026

  • 0 min

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Objective:

To evaluate whether enteral nutrition (EN) supplemented with pectin improves EN delivery in critically ill patients compared to usual care.

Approach:
    Key Findings:
    • Pectin may reduce diarrhea and improve feeding tolerance in critically ill patients.
    • Existing evidence on pectin's efficacy is inconsistent and primarily from observational studies or small trials.
    Interpretation:

    The study aims to evaluate whether enteral nutrition supplemented with pectin improves enteral nutrition delivery in critically ill patients compared to usual care.

    Limitations:
    • The study is limited to patients in ICU settings and may not be generalizable to all critically ill populations.
    • Potential biases inherent in open-label trial designs.
    Conclusion:

    The PROMOTE trial will assess the impact of pectin supplementation on feeding tolerance and clinical outcomes in mechanically ventilated patients.

    Sources:

Original Source(s)

The effect of pectin-supplemented enteral nutrition in mechanically ventilated patients receiving gastric feeding: protocol of a multicenter, open-label, randomized controlled trial (the PROMOTE trial)

  • by Zirui Liu, Yizhen Xu, Yuan Ding, Lin Gao, Ruixin Bai, Cheng Lv, Qian Li, Man Li, Yingqiao Bai, Xiang Li, Wei Qin, Wangye Wu, Wencheng Yang, Zhengquan Wang, Jun Lu, Yuxiu Liu, Lu Ke, Feng Zheng, Baiqiang Li, Weiqin Li

  • June 23, 2026

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