Authors' Reply: Interpreting Agreement in AI-Assisted American Society of Anesthesiologists (ASA) Classification - Summary - MDSpire
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Authors’ Response: Understanding Agreement in AI-Assisted American Society of Anesthesiologists (ASA) Classification

  • By

  • Bo-Han Lin

  • Cheng-Wei Lu

  • I-Ching Hou

  • Tzu-Yu Lin

  • Chin-E Liu

  • Chong-Sun Khoi

  • October 21, 2026

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Objective:

The article examines the objective, findings, and clinical context described in Authors’ Response: Understanding Agreement in AI-Assisted American Society of Anesthesiologists (ASA) Classification.

Approach:
  • Agreement measures: The authors clarified that the original analysis used unweighted Cohen κ for exact agreement and added linearly weighted κ to account for the ordinal ASA categories.
  • Disagreement patterns: They examined patient-level cross-tabulations of AI and clinician classifications with and without NHI data.
  • Bootstrap analysis: They used 10,000 paired patient-level bootstrap replicates, sampling 600 patients with replacement and recalculating unweighted κ and its between-condition difference.
Key Findings:
  • Weighted κ was 0.893 with NHI data and 0.560 without NHI data.
  • Unweighted κ was 0.883 (95% CI 0.841–0.946) with NHI data and 0.518 (95% CI 0.412–0.691) without it.
  • The unweighted κ difference was 0.365, with a paired-bootstrap 95% CI of 0.292–0.440.
  • All 9 disagreements among 63 patients with NHI data were between adjacent categories. Without NHI data, 16 of 17 disagreements were adjacent; one clinician-assigned ASA IV patient was classified as ASA II.
Interpretation:

The supplemental paired-bootstrap interval excludes zero and supports higher overall agreement when NHI data were included. The authors note that adjacent-category disagreements may still be clinically relevant.

Limitations:
  • The large proportion of ASA II patients and small ASA III-to-IV subgroups limit interpretation by ASA category; neither κ measure establishes comparable performance across categories.
  • Comparisons with earlier interrater research require caution because rater configuration, clinical environment, case mix, and κ weighting vary.
Conclusion:

The authors provided supplemental analyses to clarify agreement, disagreement patterns, and uncertainty in the NHI-data comparison.

Sources:

Original Source(s)

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