Evaluation of Donor Vessel Using Quantitative Flow Ratio in Patients with Chronic Total Occlusions - Summary - MDSpire

Evaluation of Donor Vessel Using Quantitative Flow Ratio in Patients with Chronic Total Occlusions

  • By

  • Xinjian Li

  • Juntao Duan

  • Lin Mi

  • Liyuan Tao

  • Xinye Xu

  • Guisong Wang

  • March 12, 2026

  • 0 min

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Objective:

To explore the agreement between µQFR and 3D-QFR for functional assessment of donor vessels in patients with chronic total occlusions (CTO), highlighting its potential clinical significance.

Key Findings:
  • 336 patients were included; 23 donor vessels were unsuitable for 3D-QFR analysis, indicating a need for careful selection in clinical settings.
  • Mean age of participants was 60.8 years; 81.2% were male, reflecting the demographic profile of CTO patients.
  • Majority of CTO lesions were located in the LAD (43.2%) and RCA (44.0%), which are critical areas for intervention.
Interpretation:

µQFR may provide a feasible alternative to 3D-QFR for assessing donor vessels in CTO patients, especially when obtaining multiple angiographic projections is challenging, potentially impacting clinical decision-making.

Limitations:
  • Retrospective design may introduce selection bias, which should be considered when interpreting results.
  • Limited data on the agreement between µQFR and 3D-QFR specifically for collateral donor vessels, indicating a gap in the literature.
Conclusion:

The study suggests that µQFR could be a viable method for functional assessment of donor vessels in CTO patients, warranting further investigation to validate its clinical utility.

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