Objective:

To systematically evaluate the anti-osteoporotic efficacy and underlying mechanisms of Semen Cuscutae and explore potential experimental factors associated with treatment efficacy using meta-analysis and machine learning.

Approach:

Key Findings:

• Semen Cuscutae significantly increased femoral and lumbar spine BMD.
• Improved trabecular micro-architecture was observed (increased BV/TV and Tb.Th; decreased Tb.Sp).
• Enhanced biomechanical strength was noted, though specific metrics should be clarified.
• Semen Cuscutae remodeled the osteoimmune microenvironment by suppressing pro-inflammatory cytokines and bone resorption markers.
• Species, Dose, and Treatment Duration were ranked as the most important variables associated with therapeutic efficacy.

Interpretation:

Limitations:

• The study is limited to preclinical animal models, which may not fully translate to human outcomes.
• Variability in dosing protocols and animal species may affect the generalizability of the findings.

Conclusion:

Sources:

• Systematic Review Registration
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