Objective:

To investigate the association between genetically predicted triglyceride levels and the risk of psoriasis using Mendelian randomization.

Approach:

Key Findings:

• Genetically predicted triglyceride levels were associated with psoriasis, with an odds ratio of 1.17.
• Weighted median and weighted mode analyses were statistically significant, while MR-Egger and simple mode analyses were not.
• No significant association was found between genetically predicted total fatty acid levels and psoriasis in the primary analysis.

Interpretation:

The study does not establish a causal relationship or the impact of triglyceride-lowering therapy.

Limitations:

• The study did not include a formal mediation analysis to test a fatty acid–triglyceride–psoriasis pathway.
• It assessed genetic proxies rather than measured lipid levels, psoriasis severity, flare frequency, or response to therapy.
• The analysis was restricted to European-ancestry data and did not report instrument-strength statistics or the number of psoriasis cases.

Conclusion:

Further research with larger genome-wide association study data sets and updated analyses is needed to clarify the relationships among triglycerides, fatty acids, and psoriasis.

Sources:

• Medicine
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