Objective:

To develop a portable mass spectrometry method for detecting exhaled nitric oxide (NO) using a modified KN95 mask.

Approach:

Key Findings:

• The assay delivered reproducible measurements with a detection limit suitable for typical exhaled NO screening ranges.
• Humidity had little effect on detection performance, while ambient temperature influenced NO capture.
• The method successfully detected higher NO levels after ascorbic acid rinsing, indicating its sensitivity to changes in exhaled NO.

Interpretation:

Limitations:

• Ambient temperature control is necessary for optimal detection performance in point-of-care settings, as indicated by the study's findings.

Conclusion:

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