Objective:

To provide an overview of reported cases of PTHrP-associated hypercalcemia in gynecologic malignancies and evaluate pre- and postoperative biochemical parameters.

Approach:

Key Findings:

• PTHrP is involved in hypercalcemia of malignancy in gynecologic cancers, primarily evidenced by case reports.
• There is heterogeneity in the literature regarding biochemical confirmation and clinical findings.
• PTHrP is associated with increased blood calcium levels and tumor growth.

Interpretation:

Limitations:

• The literature is heterogeneous with variable levels of biochemical confirmation.
• Evidence is primarily derived from case reports.

Conclusion:

This scoping review aims to map existing evidence on PTHrP-related hypercalcemia in gynecological cancers.

Sources:

• PRISMA-ScR Guidelines
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