Hepatitis D Virus Seroconversion Rate Among People With Chronic Hepatitis B Virus Infection in France and The Gambia (Inci-D) - Summary - MDSpire

Hepatitis D Virus Seroconversion Rate Among People With Chronic Hepatitis B Virus Infection in France and The Gambia (Inci-D)

  • By

  • Patrick Ingiliz

  • Erwan Vo-Quang

  • Gibril Ndow

  • Maud Lemoine

  • Amie Ceesay

  • Sainabou Drammeh

  • Marie-Noëlle Hilleret

  • Laure Bordy

  • Thomas Decaens

  • Anne-Laure Mazialivoua

  • Yusuke Shimakawa

  • Alhagie B Touray

  • Jean-Michel Pawlotsky

  • Isabelle Chemin

  • Stephane Chevaliez

  • Vincent Leroy

  • December 26, 2025

  • 0 min

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Objective:

To evaluate the HDV superinfection rate specifically in individuals with chronic hepatitis B virus infection in France and The Gambia.

Key Findings:
  • Baseline HDV prevalence was 1.1% in The Gambia and 2.5% in France.
  • In The Gambia, 14 individuals developed HDV antibodies after a median follow-up of 5.98 years (3.85/1000 patient-years).
  • In France, 3 individuals developed HDV antibodies after a median follow-up of 2.1 years (3.70/1000 patient-years).
Interpretation:

Hepatitis Delta superinfection is significant among HBsAg-positive carriers in both regions, indicating a need for repeated HDV serology testing to improve patient management.

Limitations:
  • The study relies on retrospective data and may not capture all cases of HDV superinfection.
  • Follow-up durations varied between cohorts, potentially affecting comparability and the overall conclusions drawn.
Conclusion:

Findings support the need for regular HDV screening in HBsAg-positive individuals to improve patient management and outcomes.

Original Source(s)

Hepatitis D Virus Seroconversion Rate Among People With Chronic Hepatitis B Virus Infection in France and The Gambia (Inci-D)

  • by Patrick Ingiliz, Erwan Vo-Quang, Gibril Ndow, Maud Lemoine, Amie Ceesay, Sainabou Drammeh, Marie-Noëlle Hilleret, Laure Bordy, Thomas Decaens, Anne-Laure Mazialivoua, Yusuke Shimakawa, Alhagie B Touray, Jean-Michel Pawlotsky, Isabelle Chemin, Stephane Chevaliez, Vincent Leroy

  • December 26, 2025

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