To analyze the long-term survival outcomes of liver transplantation patients at Sapienza University of Rome from 1982 to 2022 and identify factors limiting long-term survival.
Key Findings:
5- and 10-year survival rates have improved to 70-75% and 50-60%, respectively, indicating significant advancements in liver transplantation.
Only a few studies have reported on 10- or 20-year long-term survivors post-liver transplantation, highlighting a gap in the literature.
Identified parameters limiting long-term survival include recipient age, underlying liver disease, and immunosuppression strategies, which are critical for patient management.
Interpretation:
The study highlights the advancements in liver transplantation outcomes over the past decades and emphasizes the need for further research on long-term survivors to improve clinical practices.
Limitations:
Single-institution study may limit generalizability to broader populations.
Retrospective design may introduce biases that affect the reliability of the findings.
Exclusion of certain patient groups may affect the findings and their applicability to all liver transplant patients.
Conclusion:
The study provides valuable insights into the long-term survival of liver transplant patients and identifies critical factors influencing outcomes, which can inform future research and clinical practices.
