Brolucizumab in the Treatment of Proliferative Diabetic Retinopathy: The CONDOR Randomized Clinical Trial - Summary - MDSpire

Brolucizumab in the Treatment of Proliferative Diabetic Retinopathy: The CONDOR Randomized Clinical Trial

  • By

  • Sebastian Wolf

  • Youxin Chen

  • Xiaorong Li

  • Masahiko Shimura

  • Taiji Sakamoto

  • Charles C. Wykoff

  • Andres Emanuelli

  • Hani Salehi-Had

  • Kang Yan

  • Lidija Kovacic

  • Yongsoo Kim

  • June 1, 2026

  • 0 min

Share

Objective:

To assess the efficacy and safety of brolucizumab compared to panretinal laser photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR) without concurrent diabetic macular edema (DME).

Approach:
    Key Findings:
    • Brolucizumab has a high affinity for VEGF and a low molecular weight, allowing for greater drug delivery to the retina.
    • The study included participants from 16 countries and was conducted in accordance with ethical guidelines.
    Interpretation:

    The unique properties of brolucizumab suggest potential additional efficacy in treating PDR compared to existing anti-VEGF therapies.

    Limitations:
    • Prior studies on anti-VEGF efficacy in PDR had limitations, including treatment biases and patient selection issues.
    Conclusion:

    The CONDOR study provides insights into the efficacy and safety of brolucizumab in treating PDR, highlighting its potential as a treatment alternative to PRP.

Original Source(s)

Brolucizumab in the Treatment of Proliferative Diabetic Retinopathy: The CONDOR Randomized Clinical Trial

  • by Sebastian Wolf, Youxin Chen, Xiaorong Li, Masahiko Shimura, Taiji Sakamoto, Charles C. Wykoff, Andres Emanuelli, Hani Salehi-Had, Kang Yan, Lidija Kovacic, Yongsoo Kim

  • June 1, 2026

Related Content

Keeping an Eye on Diabetes

Progress, pitfalls and the future of the UK’s Diabetic Eye Screening Program

Association of Serum and Aqueous Humor Levels of miR-199a-3p and FN1 with the Severity of Type 2 Diabetic Retinopathy in a Chinese Cohort

Clinical Case Study: Post-Surgical Antiviral Intervention Following Pterygium Excision Informed by Corneal Confocal Microscopy