Endoscopic submucosal dissection with deliberate muscularis propria exposure for curative resection of a large type 1 gastric neuroendocrine tumor: a case report - Summary - MDSpire

Endoscopic submucosal dissection with deliberate muscularis propria exposure for curative resection of a large type 1 gastric neuroendocrine tumor: a case report

  • By

  • Nana An

  • Xiuli Zheng

  • Limian Er

  • Lei Zhang

  • July 1, 2026

  • 0 min

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Objective:

To demonstrate that curative organ-preserving resection using advanced endoscopic techniques is a viable option for selected cases of large type 1 gastric neuroendocrine tumors (gNETs).

Approach:
  • Surgical Technique: Endoscopic submucosal dissection with deliberate muscularis propria exposure (ESD-MPE) was used for the junctional tumor due to its size and location, while conventional ESD was used for the gastric body lesion.
Key Findings:
  • Both lesions were confirmed as pT1b, G2 NETs with negative margins.
  • ESD-MPE is an effective minimally invasive treatment option for larger type I gNETs without metastasis.
Interpretation:

The case illustrates that with careful patient selection and advanced endoscopic techniques, curative treatment for larger type I gNETs is achievable.

Limitations:
  • The study is based on a single case report, limiting generalizability.
  • Long-term outcomes of ESD-MPE for larger type I gNETs are not discussed.
Conclusion:

ESD-MPE represents a minimally invasive approach for selected cases of large type I gNETs.

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