To investigate if longitudinal delta-radiomics from cone-beam CT can provide early indications of dysphagia in HPV+ oropharyngeal squamous cell carcinoma patients post-radiotherapy.
Key Findings:
Predictive signals for dysphagia emerged early during treatment.
The Weeks 1–4 model achieved a mean area under the curve of 0.779.
Global skewness was the highest-ranked predictor across temporal windows.
Interpretation:
Supraglottic CBCT-based delta-radiomics can provide early signals of post-radiotherapy dysphagia, enabling better management of treatment-related toxicities.
Limitations:
Limited cohort size.
Absence of external validation.
Conclusion:
The findings suggest that delta-radiomics can be a valuable tool for early prediction of dysphagia in HPV+ OPSCC, warranting further exploration.
