Experimental verification and PK/PD modeling of selective drug absorption via acupoint administration in rabbit model of rheumatoid arthritis - Summary - MDSpire

Experimental verification and PK/PD modeling of selective drug absorption via acupoint administration in rabbit model of rheumatoid arthritis

  • By

  • Zhoubo Yu

  • Jing Yang

  • Junhao Zhang

  • Yuxin He

  • Ming Liu

  • Pengfei Ren

  • Jiannan Meng

  • Rui Wang

  • June 19, 2026

  • 0 min

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Objective:

To evaluate the transdermal absorption and therapeutic effects of miRNA55 delivered via microneedles at different acupoints in a rabbit model of rheumatoid arthritis (RA).

Approach:
    Key Findings:
    • miRNA55 concentrations in the joint cavity were highest in the ST36 group.
    • PK/PD modeling showed higher efficacy values for ST36 across all three cytokines (IL-1β, TNF-α, IL-6).
    • Western blot analysis confirmed lower expression levels of inflammatory proteins in the ST36 group.
    • H&E staining showed reduced synovial erosion and lymphokine infiltration in the ST36 group compared to others.
    Interpretation:

    Conclusion:

Original Source(s)

Experimental verification and PK/PD modeling of selective drug absorption via acupoint administration in rabbit model of rheumatoid arthritis

  • by Zhoubo Yu, Jing Yang, Junhao Zhang, Yuxin He, Ming Liu, Pengfei Ren, Jiannan Meng, Rui Wang

  • June 19, 2026

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