Objective:

To conduct a revised meta-analysis examining the correlations between TNF-α-308G/A and TNF-α-238G/A polymorphisms and the susceptibility to systemic lupus erythematosus (SLE), integrating the Bayesian false discovery probability (BFDP) and a 95% prediction interval (PI) evaluation to mitigate false-positive findings.

Approach:

Key Findings:

• TNF-α-308G/A polymorphism linked with heightened SLE susceptibility across various populations.
• No meaningful association found for TNF-α-238G/A polymorphism concerning SLE susceptibility.
• Sensitivity analyses indicated a correlation of TNF-α-238G/A polymorphism with increased SLE susceptibility in overall and mixed populations.
• BFDP values for four significant associations exceeded 0.80.

Interpretation:

Limitations:

• The study was not registered and lacked a predefined protocol.
• Potential for bias in included studies not fully assessed.

Conclusion:

Attribution Notice

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