Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study - Summary - MDSpire
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Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study
To evaluate adherence to procalcitonin (PCT)-guided antibiotic management and its impact on patient outcomes in adult infectious disease patients in China, addressing real-world adherence issues.
Key Findings:
Among 195 patients, 52.3% met PCT criteria for antibiotic discontinuation.
Lower mortality rate in compliant cases (13.7% vs. 28.0%, p = 0.023).
Early discontinuation within 24 hours was associated with shorter EICU stays (7 vs. 18 days) and lower antibiotic durations (6 vs. 14 days).
No increase in mortality was observed with early discontinuation.
Interpretation:
Adherence to PCT-guided algorithms for antibiotic management is low in China, but timely discontinuation is associated with improved outcomes without increased mortality, highlighting the need for better implementation in clinical practice.
Limitations:
Retrospective design may introduce bias.
Single-center data may limit generalizability.
Potential confounding factors affecting results were not fully addressed.
Conclusion:
Further prospective studies are needed to confirm the benefits of PCT-guided antibiotic management in clinical practice, particularly focusing on adherence strategies.
