Hypnotic suggestibility as a moderator of treatment response in mild to moderate depression: an exploratory secondary analysis - Summary - MDSpire

Hypnotic suggestibility as a moderator of treatment response in mild to moderate depression: an exploratory secondary analysis

  • By

  • Julia Siewert

  • Benno Brinkhaus

  • Tatjana Tissen-Diabaté

  • Michael Teut

  • Nicolas Volz

  • July 2, 2026

  • 0 min

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Objective:

To examine whether baseline hypnotic suggestibility moderated changes in depressive symptoms over time and whether this effect varied across treatment groups.

Approach:
  • Participants: Ninety-four patients with mild to moderate depressive symptoms were randomized to group hypnosis, progressive muscle relaxation (PMR), or control, with randomization conducted using a computer-generated sequence.
Key Findings:
  • Baseline hypnotic suggestibility was not associated with differential change in depressive symptoms over time in the control group.
  • No indication that the association differed in the hypnosis or PMR group compared to the control group.
  • Post hoc power analysis indicated that group sizes were insufficient to reliably detect small-to-moderate associations.
Interpretation:

Exploratory analyses did not indicate that hypnotic suggestibility moderated changes in depressive symptoms across treatment groups.

Limitations:
  • Limited statistical power due to small sample size, which may affect the reliability of the findings.
Conclusion:

Exploratory findings suggest that larger studies are needed to further investigate treatment-response moderators.

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