To present a scalable cognitive assessment tool for aging and dementia through the Oxford Cognitive Testing Portal (OCTAL), addressing the global rise in dementia.
Key Findings:
OCTAL demonstrated equivalent task performance in English- and Chinese-speaking younger adults.
The 5-minute OCTAL screen achieved an AUC of 0.92 in distinguishing Alzheimer’s disease dementia, indicating high diagnostic accuracy.
A 20-minute subset of OCTAL surpassed the 5-minute screen with an AUC of 0.97 (p = 0.04).
Test-retest reliability was very good (ICC ≥ 0.79; N = 118).
Interpretation:
OCTAL enables effective remote cognitive assessment, making it suitable for large-scale research and clinical screening, with significant implications for improving dementia diagnosis.
Limitations:
Patient-level data are not publicly available due to privacy restrictions.
Future releases will depend on data availability for adjustments based on gender and education level, and potential biases in cohort analysis should be considered.
Conclusion:
OCTAL is a sustainable and evolvable tool for cognitive assessment in aging and dementia, with publicly available normative data that enhances its utility.
by Sijia Zhao, Sofia Toniolo, Qian-Yuan Tang, Anna Scholcz, Akke Ganse-Dumrath, Claudia Gendarini, M. John Broulidakis, Sian Thompson, Sanjay G. Manohar, Masud Husain
