Objective:

To screen differential metabolites in serum and villous tissues from patients with missed abortion and analyze their potential mechanisms and clinical implications.

Approach:

Key Findings:

• Distinct metabolic differences were observed in serum and villous tissues between missed abortion and control groups.
• Serum showed upregulated amino acid metabolism, with elevated levels of ORN and TYR linked to missed abortion risk.
• Villous tissues exhibited disturbances in acylcarnitine metabolism, with C10:1 and C18 significantly upregulated.
• No highly consistent differential metabolites were identified between serum and villous tissues, indicating localized metabolic disturbances.
• CIT was consistently upregulated in both matrices.

Interpretation:

The study provides insights into the metabolic pathogenesis of missed abortion, highlighting specific metabolic disturbances in serum and villous tissues, which may inform future research.

Limitations:

• Limited assay coverage may have affected the identification of consistent differential metabolites, potentially overlooking key metabolic changes.
• The study's findings are based on a specific population and may not be generalizable to all demographics.

Conclusion:

The findings reveal distinct metabolic signatures associated with missed abortion, suggesting potential avenues for further research into its causes and implications for clinical practice.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.