To provide multidisciplinary guidance for the management of xylazine-associated wounds (XAWs) in individuals with substance use disorder, emphasizing the need to address both medical and social aspects of care.
Key Findings:
XAWs are chronic, often large, and can become superinfected.
The prevalence of xylazine in illicit drug supplies is increasing, particularly in the northeastern US, highlighting the need for urgent care strategies.
XAWs can occur at injection sites or distant from them, presenting as various types of ulcers.
Interpretation:
XAWs represent a significant clinical challenge due to their chronic nature and potential for severe complications, necessitating a comprehensive and coordinated care approach to address the rising prevalence.
Limitations:
The pathogenesis of XAWs is not fully understood.
Diagnosis relies heavily on clinical observation and may vary in regions with less prevalence of xylazine, impacting treatment strategies.
Conclusion:
A multidisciplinary approach is essential for effective management of XAWs, addressing both medical and social aspects of care for individuals with substance use disorder.
by Wei-Teng Yang, Jessica A Meisner, Christina Maguire, Kelly E Dyer, Rachel McFadden, Ashish P Thakrar, Drew T Dickinson, Deanna Berg, Ave Preston, Michael Z David, Jeanmarie Perrone, Naasha Talati, Kathleen O Degnan
