Association of serum periostin with bone microarchitecture, muscle mass and function in Chinese postmenopausal women - Summary - MDSpire

Association of serum periostin with bone microarchitecture, muscle mass and function in Chinese postmenopausal women

  • By

  • Yiyi Gong

  • Yushuo Wu

  • Xiaosen Ma

  • Lijia Cui

  • Xiang Li

  • Qianqian Pang

  • Yue Chi

  • Ruizhi Jiajue

  • Wei Liu

  • Ou Wang

  • Mei Li

  • Xiaoping Xing

  • Zaizhu Zhang

  • Wei Yu

  • Yan Jiang

  • Weibo Xia

  • April 7, 2026

  • 0 min

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Objective:

To investigate the relationships between serum periostin and bone mineral density, bone microarchitecture, muscle mass and function, falls, and fractures in community-dwelling Chinese postmenopausal women, including the risk of falls and fractures.

Key Findings:
  • Mean serum periostin was 1770.3 ± 440.4 pmol/L.
  • Serum periostin negatively correlated with parameters of bone microarchitecture such as total area, cortical perimeter, trabecular area, and muscle mass.
  • Higher serum periostin levels were associated with increased fall risk.
Interpretation:

Higher serum periostin is linked to poorer bone microarchitecture, reduced muscle mass, and increased risk of falls, suggesting its potential as a biomarker for skeletal and muscular health in postmenopausal women, with implications for clinical assessment and future research.

Limitations:
  • Cross-sectional design limits causal inferences.
  • Study focused solely on community-dwelling women, which may not represent all postmenopausal women.
  • Sample size may limit the generalizability of the findings.
Conclusion:

Serum periostin may serve as a predictor for assessing skeletal and muscular health in postmenopausal women, highlighting the need for further research in this area.

Original Source(s)

Association of serum periostin with bone microarchitecture, muscle mass and function in Chinese postmenopausal women

  • by Yiyi Gong, Yushuo Wu, Xiaosen Ma, Lijia Cui, Xiang Li, Qianqian Pang, Yue Chi, Ruizhi Jiajue, Wei Liu, Ou Wang, Mei Li, Xiaoping Xing, Zaizhu Zhang, Wei Yu, Yan Jiang, Weibo Xia

  • April 7, 2026

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