Objective:

To evaluate perivascular diffusivity in middle cerebral artery stenosis (MCA-S) using diffusion tensor image analysis along the perivascular space (DTI-ALPS) and redirected ALPS (ro-ALPS) indices, and assess their clinical correlations.

Approach:

Key Findings:

• Both DTI-ALPS and ro-ALPS indices were significantly lower in the MCA-S group compared to healthy controls (p < 0.001).
• DTI-ALPS index negatively correlated with choroid plexus volume (r = -0.541, pFDR = 0.012).
• ro-ALPS index also showed a negative correlation with choroid plexus volume (r = -0.568, pFDR < 0.001).

Interpretation:

Remove unsupported conclusions about perivascular clearance.

Limitations:

• Study limited to a specific population and may not generalize to other demographics.
• Exclusion criteria may limit the applicability of findings to broader patient populations.

Conclusion:

Revise to avoid suggesting potential utility without direct attribution.

Attribution Notice

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