To assess the feasibility of discontinuing antihypertensive therapy (AHT) in patients on monotherapy or low-dose dual therapy and identify factors associated with maintaining normal blood pressure (normotension) without treatment for one year.
Key Findings:
36% of participants maintained blood pressure (BP) < 135/85 mmHg for one year without AHT.
Patients with baseline systolic HBPM < 120 mmHg had a 60% chance of maintaining normotension, compared to 23% for those with HBPM ≥ 120 mmHg.
One patient with systolic HBPM > 120 mmHg at baseline experienced an ischaemic stroke.
Interpretation:
Discontinuing AHT may be feasible for selected individuals with controlled hypertension and low baseline HBPM, but close monitoring is essential, particularly for those with higher baseline readings.
Limitations:
The study was non-randomized and open-label, which may introduce bias in the results.
The sample size of participants who maintained normotension was relatively small.
Conclusion:
Discontinuing AHT can be considered in selected patients with controlled hypertension, particularly those with low baseline HBPM, under careful monitoring.
Pregnant patients who sat less and moved more at light intensity had a lower risk of adverse outcomes in a prospective cohort study, but the findings do not prove causation.
