Risk factors for disease generalization in acetylcholine receptor antibody-positive ocular myasthenia: a multicenter retrospective study - Summary - MDSpire

Risk factors for disease generalization in acetylcholine receptor antibody-positive ocular myasthenia: a multicenter retrospective study

  • By

  • Lorenzo Verriello

  • Roberto Sartor

  • Fabrizio Bellizzi

  • Chiara Dalla Torre

  • Maria Elena Pessa

  • Marco Belluzzo

  • Alessio Bratina

  • Magda Quagliotto

  • Chiara Rosa Mancinelli

  • Michele Rana

  • Fulvio Pasquin

  • Martina Fabris

  • Giada Pauletto

  • Miriam Isola

  • Maria De Martino

  • Paolo Manganotti

  • Mariarosaria Valente

  • May 25, 2026

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Objective:

To identify factors associated with secondary generalization in patients with ocular-onset myasthenia gravis (OoMG) who were positive for anti–acetylcholine receptor (AChR) antibodies.

Key Findings:
  • 47.1% of patients developed generalized myasthenia gravis (gMG) during follow-up.
  • Higher anti-AChR antibody titers (HR 3.37, p = 0.002) and abnormal repetitive nerve stimulation of facial muscles (HR 2.49, p = 0.020) were associated with secondary generalization.
  • No independent predictors were identified in multivariable analysis.
Interpretation:

Higher anti-AChR antibody titers and abnormal facial repetitive nerve stimulation may indicate increased risk of secondary generalization in seropositive OoMG, although they did not independently predict generalization in multivariable analysis.

Limitations:
  • The study is retrospective and may be subject to selection bias.
  • The sample size may limit the generalizability of the findings.
Conclusion:

The combined assessment of identified factors may support early clinical risk stratification; larger prospective studies are needed to validate these findings.

Original Source(s)

Risk factors for disease generalization in acetylcholine receptor antibody-positive ocular myasthenia: a multicenter retrospective study

  • by Lorenzo Verriello, Roberto Sartor, Fabrizio Bellizzi, Chiara Dalla Torre, Maria Elena Pessa, Marco Belluzzo, Alessio Bratina, Magda Quagliotto, Chiara Rosa Mancinelli, Michele Rana, Fulvio Pasquin, Martina Fabris, Giada Pauletto, Miriam Isola, Maria De Martino, Paolo Manganotti, Mariarosaria Valente

  • May 25, 2026

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