To present a case of parathyroid carcinoma misdiagnosed as benign parathyroid hyperplasia and adenoma, emphasizing the diagnostic roles of acute urinary retention and Ki-67 proliferation index.
Key Findings:
The patient exhibited severe hypercalcemia leading to acute urinary retention, a rare presentation of parathyroid carcinoma.
Histopathological analysis revealed a Ki-67 proliferation index of 8%, indicating malignancy potential.
The initial diagnosis was complicated by misinterpretation of histopathological findings as benign, underscoring the need for interdisciplinary collaboration.
Interpretation:
Chronic hyperparathyroidism and atypical urinary symptoms should prompt a thorough reevaluation for malignancy, particularly in cases of severe hypercalcemia.
Limitations:
The case is based on a single patient experience, limiting generalizability.
Atypical presentations may not be widely recognized in clinical practice, highlighting the need for increased awareness.
Conclusion:
This case underscores the need for heightened clinical awareness of acute urinary retention as a potential indicator of parathyroid carcinoma, necessitating thorough diagnostic evaluation.
