Objective:

To report a case of acute pancreatitis that developed during COVID-19 pneumonia in a patient with a complex medical history.

Key Findings:

• The patient had elevated serum amylase and lipase levels, and CT confirmed peripancreatic inflammation.
• Acute pancreatitis was diagnosed as mild interstitial edematous pancreatitis without organ failure or complications.
• Sputum metagenomic sequencing detected SARS-CoV-2 and bacterial pathogens.

Interpretation:

The case illustrates the diagnostic complexity of acute pancreatitis in the context of COVID-19 pneumonia and multiple underlying health issues.

Limitations:

• The causal relationship between SARS-CoV-2 infection and acute pancreatitis remains controversial.
• Further advanced biliary imaging was not feasible due to the patient's condition.

Conclusion:

This case highlights the need for long-term surveillance in patients with complex medical histories and overlapping infections.