COVID Vaccine in Pregnancy: Link to Development?  - Summary - MDSpire

COVID Vaccine in Pregnancy: Link to Development? 

Multicenter study finds equivalent ASQ-3 scores at 18–30 months in offspring of vaccinated and unvaccinated mothers

  • By

  • Kerri Miller

  • February 20, 2026

  • 2 min

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Objective:

To assess neurodevelopmental outcomes in children born to mothers who received mRNA SARS-CoV-2 vaccination during or immediately before pregnancy.

Key Findings:
  • Total ASQ scores: 255 in exposed group vs 260 in unexposed group, with a median difference of -3.4 points.
  • Prespecified equivalence margin was 10 points; findings met criteria for equivalence.
  • No significant differences in secondary outcomes across multiple validated tools.
Interpretation:

The study provides reassurance regarding the safety of mRNA SARS-CoV-2 vaccination in pregnancy, showing no adverse effects on neurodevelopmental outcomes.

Limitations:
  • Potential biases due to observational study design.
  • Conflicts of interest were not disclosed.
Conclusion:

The results support the safety of mRNA COVID-19 vaccination during pregnancy with respect to child neurodevelopment.

Original Source(s)

COVID Vaccine in Pregnancy: Link to Development? 

  • by Kerri Miller

  • February 20, 2026

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